Principle Research Associate, Drug Product Process Science

Senior/Principal Research Associate, Drug Product Process Science

Contract

Cambridge, MA

• We seek a skilled and motivated scientist to work in a tight-knit team developing mRNA formulations and scaled processes. The selected candidate will contribute to a portfolio of scientific initiatives with the goal of elucidating fundamental principles behind the assembly, purification, and stabilization of mRNA delivery systems. We seek applicants that are proactive, enthusiastic, and show a passion for science. Applicants should have exceptional time management and communications skills with strengths in experimental design and execution. Previous experience with lipid nanoparticles (LNPs), tangential flow filtration, and chemical/biophysical characterization of nanoparticles is preferred. The position will support cross-functional teams across CMC, Research and Development, Production, and Drug Product Analytical Development

Here’s What You’ll Do:

• Design and execute experiments that advance fundamental understanding of mRNA lipid nanoparticle synthesis and stabilization.
• Evaluate and scale existing and novel process modes.
• Characterize nanoparticle physicochemical properties through collaboration with the Drug Product Analytical team.
• Analyze, interpret, and document experimental data and communicate outcomes to the Drug Product team and stakeholders.
• Collect and share relevant academic literature, leverage external consultants/SMEs, and establish new collaborations with internal groups.

Here’s What You’ll Bring to the Table:

• BS in Chemical Engineering, Chemistry, Pharmaceutical Science or related field with 2-5 years or MS with 0-2 years of industry experience in Pharmaceutical or Biotechnology development.
• Experience in the development of nanoparticle products and processes.
  • Preferred: experience with lipid nanoparticle (LNP) preparation and optimization. Experience with tangential flow filtration.
• Experience with chemical and biophysical characterization tools for drug delivery systems.
• Motivated, detail oriented, and shows a passion for science.
• Comfortable working in a dynamic environment.
• Flexible, adaptable in collaborations.
• Ability to manage multiple projects and communicate progress and challenges.
• Driven to complete assignments.