Senior/Principal Research Associate, Drug Product Process Science

Contract

Cambridge, MA

The Role:

We seek a skilled and motivated scientist to work in a tight-knit team developing mRNA formulations and scaled processes. The selected candidate will contribute to a portfolio of scientific initiatives with the goal of elucidating fundamental principles behind the assembly, purification, and stabilization of mRNA delivery systems. We seek applicants that are proactive, enthusiastic, and show a passion for science. Applicants should have exceptional time management and communications skills with strengths in experimental design and execution. Previous experience with lipid nanoparticles (LNPs), tangential flow filtration, and chemical/biophysical characterization of nanoparticles is preferred. The position will support cross-functional teams across CMC, Research and Development, Production, and Drug Product Analytical Development

Here’s What You’ll Do:

Design and execute experiments that advance fundamental understanding of mRNA lipid nanoparticle synthesis and stabilization.
Evaluate and scale existing and novel process modes.
Characterize nanoparticle physicochemical properties through collaboration with the Drug Product Analytical team.
Analyze, interpret, and document experimental data and communicate outcomes to the Drug Product team and stakeholders.
Collect and share relevant academic literature, leverage external consultants/SMEs, and establish new collaborations with internal groups.

Here’s What You’ll Bring to the Table:

BS in Chemical Engineering, Chemistry, Pharmaceutical Science or related field with 2-5 years or MS with 0-2 years of industry experience in Pharmaceutical or Biotechnology development.
Experience in the development of nanoparticle products and processes.
- Preferred: experience with lipid nanoparticle (LNP) preparation and optimization. Experience with tangential flow filtration.
Experience with chemical and biophysical characterization tools for drug delivery systems.
Motivated, detail oriented, and shows a passion for science.
Comfortable working in a dynamic environment.
Flexible, adaptable in collaborations.
Ability to manage multiple projects and communicate progress and challenges.
Driven to complete assignments.